publications & patents

Here is a curated list of our publications and blog post on big data in Biology.

  • Preclinical in vitro and in vivo evaluation of CD8αβ+ CD19 CAR IPSC T cells generated in a TCR signal-independent manner using DLL4/VCAM- coupled microbeads. Cancer Research 84 (6_Supplement), 39-39, 2024.
  • Deconvolution of clinical variance in CAR-T cell pharmacology and response. Nature Biotechnology 41 (11), 1606- 1617, Feb 27, 2023. 
  • Apparatus and methods for a knowledge processing system that applies a reasoning technique for cell-based analysis to predict a clinical outcome. US Patent WO2023178104A2 
  • DLL4 and VCAM on paramagnetic beads replicates thymic Notch signalling and enables differen0a0on of functional of iPSC-derived TCR T-cells in vitro. Journal for ImmunoTherapy of Cancer 11 (Suppl 1), 2023. 
  • Generation of Multipotent Lymphoid-Competent CD34+ Hematopoie0c Progenitor Cells from Human Induced Pluripotent Stem Cells. Keystone – Emerging Cellular Therapies at the Forefront of Cancer Immunotherapy, Jan 2023. 
  • MAD7-based gene editing platform for rapid and efficient iPSC engineering. Keystone, Feb, 2023. 
  • Method for generating T cell lineage populations from stem/progenitor cells. (2023, Patent filed in US, Canada) 
  • In-vitro derived T cell populations, methods of generations and usage. (2023, Patent filed in US, Canada)
  • T cell differentiation from induced pluripotent stem cell-derived blood progenitors using DLL4/VCAM coated beads. ISSCR 1258782 (Industry Breakthrough), 2022. 
  • Identification and stratification of systemic lupus erythematosus patients into two transcrip0onally distinct clusters based on IFN-I signature. Lupus 30 (5), 762-774, Jan 2021. 
  • Transporter activity changes in nonalcoholic steatohepatitis: assessment with plasma coproporphyrin I and III. Journal of Pharmacology and Experimental Therapeu0cs. 376 (1), 29-39. Jan 2021. 
  • Multiple Myeloma DREAM Challenge reveals epigenetic regulators PHF19 as marker of aggressive disease. Leukemia 34, 1866-1874, 2020.
  • Considerations for optimization of high-throughput sequencing bioinformatics pipelines for virus detection. Viruses 10 (10), 528, Sep, 2018. 
  • A multicenter study to evaluate the performance of high-throughput sequencing for virus detection. Msphere 2 (5), 10.1128/msphere. 00307-17. Sep, 2017. 
  • Development of a candidate reference material for adventitious virus detection in vaccine and biological manufacturing by deep sequencing. Vaccine 34 (17), 2035-43. Apr, 2016. 
  • A multivariate approach to data analysis of vaccine clinical trials. The Journal of Immunology 196 (1_Supplement), 215.11-215.11, May 2016.
  • Systems approach for the selection of micro-RNAs as therapeutic biomarkers of anti-EGFR monoclonal antibody treatment in colorectal cancer. Scientific Reports 5 (1), 8013. Jan 2015. 
  • Molecular biomarkers in clinical development: what could we learn from the clinical trial registry? Personalized Medicine 11 (4), 381-393. Jun 2014. 
  • Challenges and opportuni0es for oncology biomarker discovery. Drug Discovery Today 18 (13-14), 614-624. Jul, 2013. 

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